1) Ranolazine: reduces late Na influx and Ca influx into myocardial cells during ischemia, reduces diastolic myocardial tension and increases blood flow to ischemic zones 2) Trimetazidine: modulates myocardial metabolism, inhibits use of FFAs as energy source and shifting the myocardial metabolism to glucose utilization which requires less oxygen than FFAs 3) Nicorandil: activates (opens) ATP sensitive K channels and promotes K ions outflow from cells resulting in hyperpolarization of membrane with reduction in vascular tone (preconditioning)

4) Ivabradine: selective If channel blocker in sinus node. Slows the rate of diastolic depolarization and heart rate 5) Allopurinol: inhibits xanthine oxidase (XO)